life chemicals diversity set  (Life Chemicals Inc)

Journal: ACS Infectious Diseases

Article Title: High-Throughput Screening of More Than 30,000 Compounds for Anthelmintics against Gastrointestinal Nematode Parasites

doi: 10.1021/acsinfecdis.4c00327

Figure Lengend Snippet: Screening Summary of 30,238 Compounds from 13 Different Libraries with Information on Screening Doses, the Number of Hits per Screening Model, and the Hit Rates

Article Snippet: We identified seven compounds with broad anthelmintic activity from the Life Chemicals Diversity Set, which is compiled of de novo and newly synthesized molecules developed for initial phenotypic screening.

Techniques:

Journal: Biomolecules

Article Title: De Novo Design of Inhibitors of DNA Methyltransferase 1: A Critical Comparison of Ligand- and Structure-Based Approaches

doi: 10.3390/biom14070775

Figure Lengend Snippet: Training chemical libraries used for alvaBuilder as fragment sources.

Article Snippet: Life Chemicals Soluble Fragments [ ] , Diversity-oriented fragment library with experimental solubility data. , 1280.

Techniques:

Journal: Biomolecules

Article Title: De Novo Design of Inhibitors of DNA Methyltransferase 1: A Critical Comparison of Ligand- and Structure-Based Approaches

doi: 10.3390/biom14070775

Figure Lengend Snippet: Fragment libraries used for the de novo design with LigBuilder.

Article Snippet: Life Chemicals Soluble Fragments [ ] , Diversity-oriented fragment library with experimental solubility data. , 1280.

Techniques: Solubility, Drug discovery

Journal: Biomolecules

Article Title: De Novo Design of Inhibitors of DNA Methyltransferase 1: A Critical Comparison of Ligand- and Structure-Based Approaches

doi: 10.3390/biom14070775

Figure Lengend Snippet: Compounds predicted as active by the FFNN + Morgan model.

Article Snippet: Life Chemicals Soluble Fragments [ ] , Diversity-oriented fragment library with experimental solubility data. , 1280.

Techniques: